diff --git a/cmd/cli/cli.go b/cmd/cli/cli.go
index 49d8b67..70c2312 100644
--- a/cmd/cli/cli.go
+++ b/cmd/cli/cli.go
@@ -901,6 +901,9 @@ func selfCheckStatus(ctx context.Context, s service.Service, sockDir string) (bo
 
 	lc := cfg.FirstListener()
 	addr := net.JoinHostPort(lc.IP, strconv.Itoa(lc.Port))
+	if needMdnsResponderHack {
+		addr = "127.0.0.1:53"
+	}
 
 	mainLog.Load().Debug().Msgf("performing listener test, sending queries to %s", addr)
 
@@ -1113,6 +1116,10 @@ func uninstall(p *prog, s service.Service) {
 		// Stop already did router.Cleanup and report any error if happens,
 		// ignoring error here to prevent false positive.
 		_ = p.router.Cleanup()
+
+		// Run mDNS responder cleanup if necessary
+		doMdnsResponderCleanup()
+
 		mainLog.Load().Notice().Msg("Service uninstalled")
 		return
 	}
@@ -1230,6 +1237,8 @@ func tryUpdateListenerConfig(cfg *ctrld.Config, infoLogger *zerolog.Logger, noti
 	nextdnsMode := nextdns != ""
 	// For Windows server with local Dns server running, we can only try on random local IP.
 	hasLocalDnsServer := hasLocalDnsServerRunning()
+	// For Macos with mDNSResponder running on port 53, we must use 0.0.0.0 to prevent conflicting.
+	needMdnsResponderHack := needMdnsResponderHack
 	notRouter := router.Name() == ""
 	isDesktop := ctrld.IsDesktopPlatform()
 	for n, listener := range cfg.Listener {
@@ -1263,6 +1272,12 @@ func tryUpdateListenerConfig(cfg *ctrld.Config, infoLogger *zerolog.Logger, noti
 				lcc[n].Port = false
 			}
 		}
+		if needMdnsResponderHack {
+			listener.IP = "0.0.0.0"
+			listener.Port = 53
+			lcc[n].IP = false
+			lcc[n].Port = false
+		}
 		updated = updated || lcc[n].IP || lcc[n].Port
 	}
 
@@ -1295,6 +1310,9 @@ func tryUpdateListenerConfig(cfg *ctrld.Config, infoLogger *zerolog.Logger, noti
 	// Created listeners will be kept in listeners slice above, and close
 	// before function finished.
 	tryListen := func(addr string) error {
+		if needMdnsResponderHack {
+			killMdnsResponder()
+		}
 		udpLn, udpErr := net.ListenPacket("udp", addr)
 		if udpLn != nil {
 			closers = append(closers, udpLn)
@@ -1358,6 +1376,9 @@ func tryUpdateListenerConfig(cfg *ctrld.Config, infoLogger *zerolog.Logger, noti
 		}
 		attempts := 0
 		maxAttempts := 10
+		if needMdnsResponderHack {
+			maxAttempts = 1
+		}
 		for {
 			if attempts == maxAttempts {
 				notifyFunc()
diff --git a/cmd/cli/commands.go b/cmd/cli/commands.go
index a1074f2..dbd13bf 100644
--- a/cmd/cli/commands.go
+++ b/cmd/cli/commands.go
@@ -359,6 +359,10 @@ NOTE: running "ctrld start" without any arguments will start already installed c
 
 				initInteractiveLogging()
 				tasks := []task{
+					{func() error {
+						doMdnsResponderCleanup()
+						return nil
+					}, false, "Cleanup service before installation"},
 					{func() error {
 						// Save current DNS so we can restore later.
 						withEachPhysicalInterfaces("", "saveCurrentStaticDNS", func(i *net.Interface) error {
@@ -374,6 +378,10 @@ NOTE: running "ctrld start" without any arguments will start already installed c
 					}, false, "Configure service failure actions"},
 					{s.Start, true, "Start"},
 					{noticeWritingControlDConfig, false, "Notice writing ControlD config"},
+					{func() error {
+						doMdnsResponderHackPostInstall()
+						return nil
+					}, false, "Configure service post installation"},
 				}
 				mainLog.Load().Notice().Msg("Starting existing ctrld service")
 				if doTasks(tasks) {
@@ -437,6 +445,10 @@ NOTE: running "ctrld start" without any arguments will start already installed c
 			}
 
 			tasks := []task{
+				{func() error {
+					doMdnsResponderCleanup()
+					return nil
+				}, false, "Cleanup service before installation"},
 				{s.Stop, false, "Stop"},
 				{func() error { return doGenerateNextDNSConfig(nextdns) }, true, "Checking config"},
 				{func() error { return ensureUninstall(s) }, false, "Ensure uninstall"},
@@ -459,6 +471,10 @@ NOTE: running "ctrld start" without any arguments will start already installed c
 				// Note that startCmd do not actually write ControlD config, but the config file was
 				// generated after s.Start, so we notice users here for consistent with nextdns mode.
 				{noticeWritingControlDConfig, false, "Notice writing ControlD config"},
+				{func() error {
+					doMdnsResponderHackPostInstall()
+					return nil
+				}, false, "Configure service post installation"},
 			}
 			mainLog.Load().Notice().Msg("Starting service")
 			if doTasks(tasks) {
diff --git a/cmd/cli/dns_proxy.go b/cmd/cli/dns_proxy.go
index 3d8cc30..60dfd49 100644
--- a/cmd/cli/dns_proxy.go
+++ b/cmd/cli/dns_proxy.go
@@ -101,6 +101,15 @@ func (p *prog) serveDNS(listenerNum string) error {
 			_ = w.WriteMsg(answer)
 			return
 		}
+		// When mDNSResponder hack has been done, ctrld was listening on 0.0.0.0:53, but only requests
+		// to 127.0.0.1:53 are accepted. Since binding to 0.0.0.0 will make the IP info of the local address
+		// hidden (appeared as [::]), we checked for requests originated from 127.0.0.1 instead.
+		if needMdnsResponderHack && !strings.HasPrefix(w.RemoteAddr().String(), "127.0.0.1:") {
+			answer := new(dns.Msg)
+			answer.SetRcode(m, dns.RcodeRefused)
+			_ = w.WriteMsg(answer)
+			return
+		}
 		listenerConfig := p.cfg.Listener[listenerNum]
 		reqId := requestID()
 		ctx := context.WithValue(context.Background(), ctrld.ReqIdCtxKey{}, reqId)
@@ -854,6 +863,9 @@ func runDNSServer(addr, network string, handler dns.Handler) (*dns.Server, <-cha
 	errCh := make(chan error)
 	go func() {
 		defer close(errCh)
+		if needMdnsResponderHack {
+			killMdnsResponder()
+		}
 		if err := s.ListenAndServe(); err != nil {
 			s.NotifyStartedFunc()
 			mainLog.Load().Error().Err(err).Msgf("could not listen and serve on: %s", s.Addr)
diff --git a/cmd/cli/mdnsresponder_hack_darwin.go b/cmd/cli/mdnsresponder_hack_darwin.go
new file mode 100644
index 0000000..6687bc5
--- /dev/null
+++ b/cmd/cli/mdnsresponder_hack_darwin.go
@@ -0,0 +1,154 @@
+package cli
+
+import (
+	"bufio"
+	"errors"
+	"io"
+	"os"
+	"os/exec"
+	"path/filepath"
+	"strings"
+
+	"tailscale.com/net/netmon"
+)
+
+// On macOS, the system daemon mDNSResponder (used for proxy/mDNS/Bonjour discovery)
+// listens on UDP and TCP port 53. That conflicts with ctrld when it needs to
+// run a DNS proxy on port 53. The kernel does not allow two processes to bind
+// the same address/port, so ctrld would fail with "address already in use" if we
+// did nothing.
+//
+// If ctrld started before mDNSResponder and listened only on 127.0.0.1, mDNSResponder
+// would bind port 53 on other interfaces, so system processes would use it as the
+// DNS resolver instead of ctrld, leading to inconsistent behavior.
+//
+// This file implements a Darwin-only workaround:
+//
+//   - We detect at startup whether mDNSResponder is using port 53 (or a
+//     persisted marker file exists from a previous run).
+//   - When the workaround is active, we force the listener to 0.0.0.0:53 and,
+//     before binding, run killall mDNSResponder so that ctrld can bind to port 53.
+//   - We use SO_REUSEPORT (see listener setup) so that the socket can be bound
+//     even when the port was recently used.
+//   - On install we create a marker file in the user's home directory so that
+//     the workaround is applied on subsequent starts; on uninstall we remove
+//     that file and bounce the en0 interface to restore normal mDNSResponder
+//     behavior.
+//
+// Without this, users on macOS would be unable to run ctrld as the system DNS
+// on port 53 when mDNSResponder is active.
+
+var (
+
+	// needMdnsResponderHack determines if a system-specific workaround for mDNSResponder is necessary at runtime.
+	needMdnsResponderHack     = mDNSResponderHack()
+	mDNSResponderHackFilename = ".mdnsResponderHack"
+)
+
+// mDNSResponderHack checks if the mDNSResponder process and its environments meet specific criteria for operation.
+func mDNSResponderHack() bool {
+	if st, err := os.Stat(mDNSResponderFile()); err == nil && st.Mode().IsRegular() {
+		return true
+	}
+	out, err := lsofCheckPort53()
+	if err != nil {
+		return false
+	}
+	if !isMdnsResponderListeningPort53(strings.NewReader(out)) {
+		return false
+	}
+	return true
+}
+
+// mDNSResponderFile constructs and returns the absolute path to the mDNSResponder hack file in the user's home directory.
+func mDNSResponderFile() string {
+	if d, err := userHomeDir(); err == nil && d != "" {
+		return filepath.Join(d, mDNSResponderHackFilename)
+	}
+	return ""
+}
+
+// doMdnsResponderCleanup performs cleanup tasks for the mDNSResponder hack file and resets the network interface "en0".
+func doMdnsResponderCleanup() {
+	fn := mDNSResponderFile()
+	if fn == "" {
+		return
+	}
+	if st, err := os.Stat(fn); err != nil || !st.Mode().IsRegular() {
+		return
+	}
+	if err := os.Remove(fn); err != nil {
+		mainLog.Load().Error().Err(err).Msg("failed to remove mDNSResponder hack file")
+	}
+
+	ifName := "en0"
+	if din, err := netmon.DefaultRouteInterface(); err == nil {
+		ifName = din
+	}
+	if err := exec.Command("ifconfig", ifName, "down").Run(); err != nil {
+		mainLog.Load().Error().Err(err).Msg("failed to disable en0")
+	}
+	if err := exec.Command("ifconfig", ifName, "up").Run(); err != nil {
+		mainLog.Load().Error().Err(err).Msg("failed to enable en0")
+	}
+}
+
+// doMdnsResponderHackPostInstall creates a hack file for mDNSResponder if required and logs debug or error messages.
+func doMdnsResponderHackPostInstall() {
+	if !needMdnsResponderHack {
+		return
+	}
+	fn := mDNSResponderFile()
+	if fn == "" {
+		return
+	}
+	if f, err := os.OpenFile(fn, os.O_RDWR|os.O_CREATE|os.O_TRUNC, 0400); err != nil {
+		mainLog.Load().Warn().Err(err).Msgf("Could not create %s", fn)
+	} else {
+		if err := f.Close(); err != nil {
+			mainLog.Load().Warn().Err(err).Msgf("Could not close %s", fn)
+		} else {
+			mainLog.Load().Debug().Msgf("Created %s", fn)
+		}
+	}
+}
+
+// killMdnsResponder attempts to terminate the mDNSResponder process by running the "killall" command multiple times.
+// Logs any accumulated errors if the attempts to terminate the process fail.
+func killMdnsResponder() {
+	numAttempts := 10
+	errs := make([]error, 0, numAttempts)
+	for range numAttempts {
+		if err := exec.Command("killall", "mDNSResponder").Run(); err != nil {
+			// Exit code 1 means the process not found, do not log it.
+			if !strings.Contains(err.Error(), "exit status 1") {
+				errs = append(errs, err)
+			}
+		}
+	}
+	if len(errs) > 0 {
+		mainLog.Load().Debug().Err(errors.Join(errs...)).Msg("failed to kill mDNSResponder")
+	}
+}
+
+// lsofCheckPort53 executes the lsof command to check if any process is listening on port 53 and returns the output.
+func lsofCheckPort53() (string, error) {
+	cmd := exec.Command("lsof", "+c0", "-i:53", "-n", "-P")
+	out, err := cmd.CombinedOutput()
+	if err != nil {
+		return "", err
+	}
+	return string(out), nil
+}
+
+// isMdnsResponderListeningPort53 checks if the output provided by the reader contains an mDNSResponder process.
+func isMdnsResponderListeningPort53(r io.Reader) bool {
+	scanner := bufio.NewScanner(r)
+	for scanner.Scan() {
+		fields := strings.Fields(scanner.Text())
+		if len(fields) > 0 && strings.EqualFold(fields[0], "mDNSResponder") {
+			return true
+		}
+	}
+	return false
+}
diff --git a/cmd/cli/mdnsresponder_hack_others.go b/cmd/cli/mdnsresponder_hack_others.go
new file mode 100644
index 0000000..5d6ada5
--- /dev/null
+++ b/cmd/cli/mdnsresponder_hack_others.go
@@ -0,0 +1,21 @@
+//go:build !darwin
+
+package cli
+
+// needMdnsResponderHack determines if a system-specific workaround for mDNSResponder is necessary at runtime.
+var needMdnsResponderHack = mDNSResponderHack()
+
+// mDNSResponderHack checks if the mDNSResponder process and its environments meet specific criteria for operation.
+func mDNSResponderHack() bool {
+	return false
+}
+
+// killMdnsResponder attempts to terminate the mDNSResponder process by running the "killall" command multiple times.
+// Logs any accumulated errors if the attempts to terminate the process fail.
+func killMdnsResponder() {}
+
+// doMdnsResponderCleanup performs cleanup tasks for the mDNSResponder hack file and resets the network interface "en0".
+func doMdnsResponderCleanup() {}
+
+// doMdnsResponderHackPostInstall creates a hack file for mDNSResponder if required and logs debug or error messages.
+func doMdnsResponderHackPostInstall() {}