diff --git a/erpnext/selling/doctype/quotation/quotation.py b/erpnext/selling/doctype/quotation/quotation.py
index 6d9c170aef0..ad06bd2ddba 100644
--- a/erpnext/selling/doctype/quotation/quotation.py
+++ b/erpnext/selling/doctype/quotation/quotation.py
@@ -185,6 +185,7 @@ def _make_sales_invoice(source_name, target_doc=None, ignore_permissions=False):
 		target.run_method("calculate_taxes_and_totals")
 
 	def update_item(obj, target, source_parent):
+		target.cost_center = None
 		target.stock_qty = flt(obj.qty) * flt(obj.conversion_factor)
 
 	doclist = get_mapped_doc("Quotation", source_name, {